Literature will be provided during the course. To understand how the host immune system modulates disease progression. To understand which elements in the various signaling pathways represent candidate drug targets for treatment of cancer and atherosclerosis. To gain insight in the role of the various signaling pathways in development and progression of cancer and atherosclerosis. To gain knowledge on the functioning and regulation of kinases, phosphatases, adhesion receptors, G-protein coupled receptors, nuclear hormone receptors, cytokine and their receptors. To understand the overall concept that alterations in cell signaling pathways are involved in disease development and progression. To gain insight in the basic concepts of cellular signal transduction The aim of the CST course is to provide a strong basis for the understanding of cellular signal transduction, its role in disease, and its application in drug development. We will further illustrate in what way these signaling pathways are involved in disease development and progression and how we can make use of this knowledge to develop novel therapeutic strategies using cancer and atherosclerosis as examples. Moreover, we will discuss how these different signaling pathways are also integrated in complex signaling networks that control biological outcome. We will discuss how these receptors are activated and which downstream signaling pathways are subsequently activated. The course will discuss the concepts of cellular signal transduction and focus on (receptor) kinases, G-protein coupled receptors, cytokine receptors, and nuclear hormone receptors. Given the involvement of perturbed signaling in disease, components of signaling networks are important candidate drug targets. In atherosclerosis, immune signaling is essential to promote plaque formation. Mutations in signaling pathways that drive cell proliferation are key to cancer development and progression. The role of Signal transduction pathways involving (receptor) kinases, G-protein coupled receptors, adhesion receptors, cytokine receptors, and nuclear hormone receptors in disease development, progression and drug development is discussed.ĭisease development and progression is largely due to the activation and or modulation of cellular signaling. In addition, researchers utilize mouse genetics approaches alongside the traditional tools of biochemistry and molecular biology to connect these signaling pathways to the broader goal of defining whether disruption of these pathways participates in the pathogenesis of human disease.This course will discuss the basic concepts of cellular signal transduction. To accomplish these goals a variety of state-of-the-art techniques are applied and novel approaches to the study of signaling molecules are developed here in this department. The study of signal transduction in Pharmacology at Yale is particularly exciting because of the potential impact that uncovering how these complex networks work might have on human disease. How cells sense their environment through adhesion molecules and membrane channels are also areas of signal transduction research conducted in this department. In many instances the inter-connectivity of these intracellular signaling pathways provides a portal to the outside world. Other areas of interest focus on the actions of G-protein-coupled receptors, phospholipids, calcium and gases as intracellular transducers. These research interests include the regulation of signal transduction by protein phosphorylation through the actions of protein kinases and protein phosphatases. The strength of signal transduction research in the Department of Pharmacology is built upon an integrated platform from which faculty from different disciplines collaborate and bring to bear their expertise to solve a variety of distinct problems in the area of cell signaling. Signal transduction in Pharmacology provides the unique opportunity to uncover the basis of human disease and ultimately the development of novel therapeutic strategies to treat cancer, cardiovascular, neurological and metabolic disorders. The value that this information offers to the well-being of humans is immense. SIGNAL TRANSDUCTION SERIESUnderstanding this complex series of inter-connected cascades inside the cell will eventually provide a detailed roadmap for how cells work. Here in the Department of Pharmacology at Yale, signal transduction is studied in a variety of different ways to understand how a cell transduces signals from the plasma membrane to the nucleus. How does a cell know what to do and when to do it? This question forms the basis for the field of research called signal transduction.
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